It may result in formation of granuloma 
Mitomycin works 2/3 weeks after wound healing so it has no effect at the time of surgery 
It is expensive also 
Wound healing has three phases
Inflammation immediate 
Proliferation 2nd day 
Maturation 2 weeks 
eschar can be removed at second stage when mitomycin can be applied 
Don't inject epinephrine in larynx as it may stop bleeding then but bleeding may start later when it's effects is off. 
 
